Cross-modal distillation transfers spatial transcriptomics-derived tissue niche structures to histology-only models, yielding higher agreement with molecular niches than unsupervised image-feature baselines across tissues and diseases.
STPath: a generative foundation model for integrating spatial transcrip- tomics and whole-slide images.npj Digital Medicine, 8(1): 659
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Cross-Modal Knowledge Distillation from Spatial Transcriptomics to Histology
Cross-modal distillation transfers spatial transcriptomics-derived tissue niche structures to histology-only models, yielding higher agreement with molecular niches than unsupervised image-feature baselines across tissues and diseases.