In generalized contrastive learning with imbalanced classes, optimal representations collapse to class means whose angular geometry is determined by class proportions via convex optimization, and extreme imbalance causes all minority classes to collapse to one vector.
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PerturbedVAE disentangles perturbation-specific signals from invariant gene expression structure to recover causal representations and improve out-of-distribution prediction in single-cell perturbation modeling.
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Optimal Representations for Generalized Contrastive Learning with Imbalanced Datasets
In generalized contrastive learning with imbalanced classes, optimal representations collapse to class means whose angular geometry is determined by class proportions via convex optimization, and extreme imbalance causes all minority classes to collapse to one vector.
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What Makes a Representation Good for Single-Cell Perturbation Prediction?
PerturbedVAE disentangles perturbation-specific signals from invariant gene expression structure to recover causal representations and improve out-of-distribution prediction in single-cell perturbation modeling.