A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.
Hybrid deep modeling of a cho-k1 fed-batch process: combining first-principles with deep neural networks.Frontiers in Bioengineering and Biotechnology, 11:1237963, 2023
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GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.