Simulation study finds 5-state multistate models for MCED data perform similarly to 3-state models in robustness while 9-state models lose identifiability and precision, with hierarchical models and informative priors offering partial improvements.
The National Health Service-Galleri multi-cancer screening trial: explanation and justification of unique and important design issues
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Modelling multi-cancer screening data to infer on natural history of disease: when can valid, identifiable and precise inference be obtained?
Simulation study finds 5-state multistate models for MCED data perform similarly to 3-state models in robustness while 9-state models lose identifiability and precision, with hierarchical models and informative priors offering partial improvements.