Intervention-aware distillation transfers mechanistic knowledge from perturbational transcriptomics to imaging phenomics for improved one-shot transfer to unseen drugs and target gene discovery.
A pooled cell painting crispr screening platform enables de novo inference of gene function by self-supervised deep learning.bioRxiv, pages 2023–08
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Intervention-Aware Multiscale Representation Learning from Imaging Phenomics and Perturbation Transcriptomics
Intervention-aware distillation transfers mechanistic knowledge from perturbational transcriptomics to imaging phenomics for improved one-shot transfer to unseen drugs and target gene discovery.