Covariate adjustment for the win odds becomes feasible by connecting it to the marginal probabilistic index, yielding more precise estimators and increased power in CVOTs when covariates are prognostic.
Covariate adjustment in randomized controlled trials: General concepts and practical considerations.Clinical Trials, 21(4):399– 411
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Covariate Adjustment for the Win Odds: Application to Cardiovascular Outcomes Trials
Covariate adjustment for the win odds becomes feasible by connecting it to the marginal probabilistic index, yielding more precise estimators and increased power in CVOTs when covariates are prognostic.