BioInsight is a multi-agent system that generates interactive, provenance-preserving biomedical evidence interfaces from disease names and protein data.
Towards Trustworthy Report Generation: A Deep Research Agent with Progressive Confidence Estimation and Calibration
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abstract
As agent-based systems continue to evolve, deep research agents are capable of automatically generating research-style reports across diverse domains. While these agents promise to streamline information synthesis and knowledge exploration, existing evaluation frameworks-typically based on subjective dimensions-fail to capture a critical aspect of report quality: trustworthiness. In open-ended research scenarios where ground-truth answers are unavailable, current evaluation methods cannot effectively measure the epistemic confidence of generated content, making calibration difficult and leaving users susceptible to misleading or hallucinated information. To address this limitation, we propose a novel deep research agent that incorporates progressive confidence estimation and calibration within the report generation pipeline. Our system leverages a deliberative search model, featuring deep retrieval and multi-hop reasoning to ground outputs in verifiable evidence while assigning confidence scores to individual claims. Combined with a carefully designed workflow, this approach produces trustworthy reports with enhanced transparency. Experimental results and case studies demonstrate that our method substantially improves interpretability and significantly increases user trust.
fields
cs.AI 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
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BioInsight: Multi-Agent Orchestration for Interactive Biomedical Knowledge Discovery
BioInsight is a multi-agent system that generates interactive, provenance-preserving biomedical evidence interfaces from disease names and protein data.