TCR-SRIM uses structure regularization and contact prototypes for interpretable TCR-epitope binding prediction, reports SOTA performance on TCR-XAI, and finds generated structures produce less accurate interaction patterns than experimental ones.
Analyzing the mycobacterium tuberculosis immune response by t-cell receptor clustering with gliph2 and genome-wide antigen screening.Nature biotechnology, 38(10):1194–1202, 2020
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Structure-Regularized Interpretable TCR-Epitope Prediction
TCR-SRIM uses structure regularization and contact prototypes for interpretable TCR-epitope binding prediction, reports SOTA performance on TCR-XAI, and finds generated structures produce less accurate interaction patterns than experimental ones.