ATHENA-R1 is an RL-trained agent using 212 biomedical tools that achieves 94.7% accuracy on drug reasoning and 82.9% on treatment reasoning tasks, outperforming GPT-5 by 17.8 and 10.7 points respectively.
The next- generation Open Targets Platform: reimagined, redesigned, rebuilt.Nucleic Acids Research, 51 (D1):D1353–D1359, 2023
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Post-training stages reshape generalization in biological reasoning models distinctly: CPT aligns with biological language, SFT boosts ID performance but causes OOD to peak early and decline, while RL on strong SFT checkpoints can recover OOD generalization.
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An AI agent for treatment reasoning over a biomedical tool universe
ATHENA-R1 is an RL-trained agent using 212 biomedical tools that achieves 94.7% accuracy on drug reasoning and 82.9% on treatment reasoning tasks, outperforming GPT-5 by 17.8 and 10.7 points respectively.
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How Post-Training Shapes Biological Reasoning Models
Post-training stages reshape generalization in biological reasoning models distinctly: CPT aligns with biological language, SFT boosts ID performance but causes OOD to peak early and decline, while RL on strong SFT checkpoints can recover OOD generalization.