CHRep improves spatial gene expression prediction from H&E slides via topology-preserving representation learning plus post-hoc calibration, reporting up to 39.5% higher Pearson correlation and reduced errors under leave-one-slide-out evaluation across three cohorts.
Identifying multicellular spatiotemporal organization of cells with SpaceFlow
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CHRep: Cross-modal Histology Representation and Post-hoc Calibration for Spatial Gene Expression Prediction
CHRep improves spatial gene expression prediction from H&E slides via topology-preserving representation learning plus post-hoc calibration, reporting up to 39.5% higher Pearson correlation and reduced errors under leave-one-slide-out evaluation across three cohorts.