A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.
Simulation and inference algorithms for stochastic biochemical reaction networks: from basic concepts to state-of-the-art.Journal of the Royal Society Interface, 16(151), 2019
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GlycoMAC: A Multiscale Metabolic-Glycosylation Framework for Predicting Glycosylation Across Conditions in Mammalian Cell Cultures
A new multiscale framework combines single-cell kinetic metabolic-glycosylation models with stochastic population dynamics and an oxygen uptake biomarker to predict cell density, metabolites, productivity, and glycan profiles in mammalian cell cultures.