Instantons and Spin-Flavor effects in Hadron Physics

We discuss the role of instantons in the spectroscopy of ordinary and exotic hadrons as well as in high energy reactions. We argue that the instanton induced flavor- and spin-dependent quark-quark and quark-gluon interactions can explain many features of the hadron spectrum. The observed anomalous spin and flavor effects in various reactions with hadrons can also be understood within the instanton model for QCD vacuum.