Neural-network simulations of memory consolidation and reconsolidation

In the mammalian brain newly acquired memories depend on the hippocampus for maintenance and recall, but over time these functions are taken over by the neocortex through a process called systems consolidation. However, reactivation of a consolidated memory can induce a brief period of temporary hippocampus-dependence, followed by return to hippocampus-independence. Here we present a computational model that uses simulation of recently described mechanisms of synaptic plasticity to account for findings from the systems consolidation/reconsolidation literature and to make predictions for future research.