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Mixture cure semiparametric additive hazard models under partly interval censoring -- a penalized likelihood approach

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arxiv 2401.01234 v1 pith:GZHQTHYK submitted 2024-01-02 stat.ME

Jinqing Li , Jun Ma This is my paper · ORCID
classification stat.ME
keywords hazardmodeladditivecuredcoefficientsgroupindividualslikelihood
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Survival analysis can sometimes involve individuals who will not experience the event of interest, forming what is known as the cured group. Identifying such individuals is not always possible beforehand, as they provide only right-censored data. Ignoring the presence of the cured group can introduce bias in the final model. This paper presents a method for estimating a semiparametric additive hazards model that accounts for the cured fraction. Unlike regression coefficients in a hazard ratio model, those in an additive hazard model measure hazard differences. The proposed method uses a primal-dual interior point algorithm to obtain constrained maximum penalized likelihood estimates of the model parameters, including the regression coefficients and the baseline hazard, subject to certain non-negativity constraints.

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Cited by 7 Pith papers

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