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Bringing closure to FDR control: beating the e-Benjamini-Hochberg procedure
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False discovery rate (FDR) has been a key metric for error control in multiple hypothesis testing, and many methods have developed for FDR control across a diverse cross-section of settings and applications. We develop a closure principle for all FDR controlling procedures, i.e., we provide a characterization based on e-values for all admissible FDR controlling procedures. A general version of this closure principle can recover any multiple testing error metric and allows one to choose the error metric post-hoc. We leverage this idea to formulate the closed eBH procedure, a (usually strict) improvement over the eBH procedure for FDR control when provided with e-values. This also yields a closed BY procedure that dominates the Benjamini-Yekutieli (BY) procedure for FDR control with arbitrarily dependent p-values, thus proving that the latter is inadmissibile. We demonstrate the practical performance of our new procedures in simulations.
Forward citations
Cited by 2 Pith papers
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Anytime-valid FDR control with the stopped e-BH procedure
Stopped e-BH controls FDR at all stopping times when the underlying e-processes are global, and local e-processes become global under a no-unobserved-confounding Markov condition.
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Carefree multiple testing with e-processes
Running-maximum e-BH can exceed the nominal FDR under arbitrary dependence, while adjusted running maxima restore FDR-sup control.
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