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arxiv: 1912.10796 · v1 · pith:BKNDHTPU · submitted 2019-12-14 · physics.ins-det · physics.bio-ph

Megahertz single-particle imaging at the European XFEL

Egor Sobolev , Serguey Zolotarev , Klaus Giewekemeyer , Johan Bielecki , Kenta Okamoto , Hemanth K. N. Reddy , Jakob Andreasson , Kartik Ayyer
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Imrich Barak Sadia Bari Anton Barty Richard Bean Sergey Bobkov Henry N. Chapman Grzegorz Chojnowski Benedikt J. Daurer Katerina D\"orner Tomas Ekeberg Leonie Fl\"uckiger Oxana Galzitskaya Luca Gelisio Steffen Hauf Brenda G. Hogue Daniel A. Horke Ahmad Hosseinizadeh Vyacheslav Ilyin Chulho Jung Chan Kim Yoonhee Kim Richard A. Kirian Henry Kirkwood Olena Kulyk Romain Letrun Duane Loh Marc Messerschmidt Kerstin M\"uhlig Abbas Ourmazd Natascha Raab Andrei V. Rode Max Rose Adam Round Takushi Sato Robin Schubert Peter Schwander Jonas A. Sellberg Marcin Sikorski Alessandro Silenzi Changyong Song John C. H. Spence Stephan Stern Jolanta Sztuk-Dambietz Anthon Teslyuk Nicusor Timneanu Martin Trebbin Charlotte Uetrecht Britta Weinhausen Garth J. Williams P Lourdu Xavier Chen Xu Ivan Vartanyants Victor Lamzin Adrian Mancuso Filipe R. N. C. Maia
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classification physics.ins-det physics.bio-ph
keywords imagingsingle-particlex-rayraterepetitionxfeldiffractioneuropean
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The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European XFEL will soon provide 27,000 pulses per second, more than two orders of magnitude more than any other XFEL. The increased pulse rate is a key enabling factor for single-particle X-ray diffractive imaging, which relies on averaging the weak diffraction signal from single biological particles. Taking full advantage of this new capability requires that all experimental steps, from sample preparation and delivery to the acquisition of diffraction patterns, are compatible with the increased pulse repetition rate. Here, we show that single-particle imaging can be performed using X-ray pulses at megahertz repetition rates. The obtained results pave the way towards exploiting high repetition-rate X-ray free-electron lasers for single-particle imaging at their full repetition rate.

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