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MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine

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arxiv 2408.02900 v3 pith:QZQKWTIQ submitted 2024-08-06 cs.CV

classification cs.CV
keywords multimodalannotationsmedtrinity-25mmodelsmultigranularcomprehensivedatasetlarge-scale
verification ladder T0 review T1 audit T2 compute T3 formal
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This paper introduces MedTrinity-25M, a comprehensive, large-scale multimodal dataset for medicine, covering over 25 million images across 10 modalities with multigranular annotations for more than 65 diseases. These multigranular annotations encompass both global information, such as modality and organ detection, and local information like ROI analysis, lesion texture, and region-wise correlations. Unlike the existing multimodal datasets, which are limited by the availability of image-text pairs, we have developed the first automated pipeline that scales up multimodal data by generating multigranular visual and textual annotations in the form of image-ROI-description triplets without the need for any paired text descriptions. Specifically, data from over 30 different sources have been collected, preprocessed, and grounded using domain-specific expert models to identify ROIs related to abnormal regions. We then build a comprehensive knowledge base and prompt multimodal large language models to perform retrieval-augmented generation with the identified ROIs as guidance, resulting in multigranular textual descriptions. Compared to existing datasets, MedTrinity-25M provides the most enriched annotations, supporting a comprehensive range of multimodal tasks such as captioning and report generation, as well as vision-centric tasks like classification and segmentation. We propose LLaVA-Tri by pretraining LLaVA on MedTrinity-25M, achieving state-of-the-art performance on VQA-RAD, SLAKE, and PathVQA, surpassing representative SOTA multimodal large language models. Furthermore, MedTrinity-25M can also be utilized to support large-scale pre-training of multimodal medical AI models, contributing to the development of future foundation models in the medical domain. We will make our dataset available.

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Forward citations

Cited by 10 Pith papers

Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score. Full citation record

  1. MedBLINK: Probing Basic Perception in Multimodal Language Models for Medicine

    cs.AI 2025-08 conditional novelty 6.0 of 10

    Current medical multimodal models, including GPT-4o and Claude 3.5 Sonnet, fail simple perceptual tasks on medical images that human experts solve almost perfectly.

  2. Constructing Ophthalmic MLLM for Positioning-diagnosis Collaboration Through Clinical Cognitive Chain Reasoning

    cs.AI 2025-07 conditional novelty 6.0 of 10

    FundusExpert, an 8B ophthalmic MLLM trained on region-grounded cognitive-chain instructions, reports state-of-the-art QA and report-generation results, with a fitted data-scaling exponent of 0.068.

  3. Unifying Biomedical Vision-Language Expertise: Towards a Generalist Foundation Model via Multi-CLIP Knowledge Distillation

    cs.CV 2025-06 conditional novelty 6.0 of 10

    A student CLIP model distilled from nine medical CLIP teachers outperforms its teachers across most of 58 biomedical benchmarks.

  4. KokushiMD-10: Benchmark for Evaluating Large Language Models on Ten Japanese National Healthcare Licensing Examinations

    cs.CL 2025-06 conditional novelty 6.0 of 10

    KokushiMD-10 is a Japanese multimodal benchmark spanning ten healthcare licensing exams, on which no tested model passed all exams.

  5. Cross-Lingual Pitfalls: Automatic Probing Cross-Lingual Weakness of Multilingual Large Language Models

    cs.CL 2025-05 conditional novelty 6.0 of 10

    An adversarial beam-search method generates over 6,000 bilingual question pairs that reliably make multilingual LLMs perform far worse in non-English languages than in English.

  6. TextSLIP: Text Self-Supervised CLIP for Medical Report Generation

    cs.CV 2026-07 conditional novelty 5.0 of 10

    Adding ESimCSE text contrastive learning to CLIP improves medical report generation BLEU scores on brain MRI over standard CLIP by about 1-3 points.

  7. Towards Enhancing 3D Spatial Reasoning in Medical Multimodal Large Language Models

    cs.CV 2026-07 reject novelty 5.0 of 10

    A synthetic chain-of-thought dataset generated from CT reports lets a 2D-pretrained medical MLLM improve on 3D CT spatial-reasoning benchmarks.

  8. MEDIC-AD: Towards Medical Vision-Language Model's Clinical Intelligence

    cs.CV 2026-03 reject novelty 5.0 of 10

    MEDIC-AD adds anomaly-aware and difference tokens to a medical VLM, claiming SOTA lesion detection, temporal tracking, and visual grounding; the zero-shot claim is undermined by likely train/test overlap.

  9. Region-Aware Multimodal Large Language Model via SlowFast Tokenization and Pseudo-Mask Guidance for 3D CT Report Generation

    eess.IV 2025-06 conditional novelty 4.0 of 10

    MedRegion-CT integrates region-representative tokens, mask-driven segmentation tokens, and patient-specific attribute prompts into a multimodal LLM, reporting state-of-the-art scores on RadGenome-Chest CT report generation.

  10. From large language models to multimodal AI: A scoping review on the potential of generative AI in medicine

    cs.AI 2025-02 conditional novelty 3.0 of 10

    A PRISMA-ScR scoping review of 144 studies finds the field shifting from text-only LLMs to multimodal AI in medicine, with evaluation and data diversity still the main bottlenecks.

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