Pith Number

pith:2BWMTP3R

pith:2025:2BWMTP3R62HE47XN4MJJWXKRCU

not attested not anchored not stored refs pending

Incorporating estimands into meta-analyses of clinical trials

Alessandro Ghiretti, Antonia Morga, Antonio Remiro-Az\'ocar, David M. Phillippo, Emmanuelle Boutmy, Helle Lynggaard, Jay J. H. Park, Khadija Rerhou Rantell, Lise Lotte Nystrup Husemoen, Pepa Polavieja, Robert Bauer, Tatsiana Vaitsiakhovich

Different target estimands at the meta-analytical level make explicit the intercurrent event strategies driving heterogeneity in clinical trial results.

arxiv:2510.15762 v3 · 2025-10-17 · stat.AP

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\usepackage{pith}
\pithnumber{2BWMTP3R62HE47XN4MJJWXKRCU}

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Record completeness

1 Bitcoin timestamp

2 Internet Archive

3 Author claim open · sign in to claim

4 Citations open

5 Replications open

✓ Portable graph bundle live · download bundle · merged state

The bundle contains the canonical record plus signed events. A mirror can host it anywhere and recompute the same current state with the deterministic merge algorithm.

Claims

C1strongest claim

The specification of different target estimands at the meta-analytical level allows us to be explicit about the source of heterogeneity, the intercurrent event strategy, driving any potential differences in results.

C2weakest assumption

That different estimand strategies for intercurrent events can be consistently defined and applied across trials in a meta-analysis even in the absence of subject-level data from the individual studies.

C3one line summary

A framework is proposed to integrate estimands into meta-analyses of clinical trials to identify sources of heterogeneity from intercurrent event strategies and improve the external validity of pooled estimates for health technology assessment.

Formal links

1 machine-checked theorem link

Receipt and verification

First computed	2026-06-02T02:04:10.170773Z
Builder	pith-number-builder-2026-05-17-v1
Signature	Pith Ed25519 (`pith-v1-2026-05`) · public key
Schema	pith-number/v1.0

Canonical hash

d06cc9bf71f68e4e7eede3129b5d5115366a8f3e77993a2c0d2399b7f661106b

Aliases

arxiv: 2510.15762 · arxiv_version: 2510.15762v3 · doi: 10.48550/arxiv.2510.15762 · pith_short_12: 2BWMTP3R62HE · pith_short_16: 2BWMTP3R62HE47XN · pith_short_8: 2BWMTP3R

Agent API

Resolver JSON Graph JSON Events JSON Schema Signing key

Verify this Pith Number yourself

curl -sH 'Accept: application/ld+json' https://pith.science/pith/2BWMTP3R62HE47XN4MJJWXKRCU \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: d06cc9bf71f68e4e7eede3129b5d5115366a8f3e77993a2c0d2399b7f661106b

Canonical record JSON

{
  "metadata": {
    "abstract_canon_sha256": "88927c565e504312d836e64239bc9d9d49fd93e862ef40debe92b816c9351ef5",
    "cross_cats_sorted": [],
    "license": "http://creativecommons.org/licenses/by/4.0/",
    "primary_cat": "stat.AP",
    "submitted_at": "2025-10-17T15:52:04Z",
    "title_canon_sha256": "cf80c405aa3a35b6c5cfcb43e006c3921dc4e3ad8c166239e48bd407ee78766f"
  },
  "schema_version": "1.0",
  "source": {
    "id": "2510.15762",
    "kind": "arxiv",
    "version": 3
  }
}