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pith:LFCUF6IJ

pith:2026:LFCUF6IJ3CZWIKXE5VGH3FUBCL
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Cross Modality Image Translation In Medical Imaging Using Generative Frameworks

Alessia Capoccia, Ana Isabel Hern\'aiz Ferrer, Arturo Chiti, Bradley J. Erickson, Deborah Fazzini, Fabrizia Gelardi, Fatemeh Darvizeh, Filippo Ruffini, Francesco Di Feola, Francesco Gossetti, Giulia Romoli, Katrine Riklund, Liu Fang, Luca Boldrini, Marcello Di Pumpo, Michail E. Klontzas, Paola Feraco, Paolo Soda, Renato Cuocolo, Sara N. Strandberg, Seyedmehdi Payabvash, Tugba Akinci D'Antonoli, Valerio Guarrasi

GANs outperform latent models in standardized 3D medical image translation across 11 oncology datasets.

arxiv:2605.13686 v1 · 2026-05-13 · cs.CV · cs.AI

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3 Author claim open · sign in to claim
4 Citations open
5 Replications open
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Claims

C1strongest claim

GANs outperform latent generative models across all tasks, with SRGAN achieving statistically significant superiority. Our lesion-level analysis reveals that all models struggle with small lesions and that, in CT to PET synthesis, models reproduce lesion shape more reliably than absolute uptake-related intensity. Visual Turing test shows near-chance classification accuracy (56.7%).

C2weakest assumption

That uniform preprocessing, splitting, and inference rules across heterogeneous datasets and modalities do not inadvertently favor GAN architectures over latent models, and that the chosen eleven datasets adequately represent clinical variability in lesion size and contrast.

C3one line summary

A uniform benchmark across 77 experiments finds SRGAN superior to latent diffusion models for 3D medical image translation, with synthetic volumes indistinguishable from real ones in a 17-physician Turing test.

References

94 extracted · 94 resolved · 2 Pith anchors

[1] WHO, WHO compendium of innovative health technologies for low-resource settings 2024, World Health Organization WHO, 2024 2024
[2] Kjelle, et al., Cost of low-value imaging worldwide: a systematic review, Applied health economics and health policy 22 (2024) 485 2024
[3] Dayarathna, et al., Deep learning-based synthesis of MRI, CT and PET: Review and analysis, Computer Methods and Programs in Biomedicine 257 (2024) 108173 2024
[4] Doan, et al., Bridging modalities with ai: a review of ai advances in multimodal biomedical imaging, Communications Engineering 5 (2026) 30 2026
[5] M. Sherwani, S. Gopalakrishnan, A systematic literature review: deep learning techniques for synthetic medical image generation and their applications in radiotherapy, Frontiers in Radiology 4 (2024) 2024

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First computed 2026-05-18T02:44:16.993531Z
Builder pith-number-builder-2026-05-17-v1
Signature Pith Ed25519 (pith-v1-2026-05) · public key
Schema pith-number/v1.0

Canonical hash

594542f909d8b3642ae4ed4c7d968112e8c12dfdf89bc2f96d95124df5abb431

Aliases

arxiv: 2605.13686 · arxiv_version: 2605.13686v1 · doi: 10.48550/arxiv.2605.13686 · pith_short_12: LFCUF6IJ3CZW · pith_short_16: LFCUF6IJ3CZWIKXE · pith_short_8: LFCUF6IJ
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Verify this Pith Number yourself
curl -sH 'Accept: application/ld+json' https://pith.science/pith/LFCUF6IJ3CZWIKXE5VGH3FUBCL \
  | jq -c '.canonical_record' \
  | python3 -c "import sys,json,hashlib; b=json.dumps(json.loads(sys.stdin.read()), sort_keys=True, separators=(',',':'), ensure_ascii=False).encode(); print(hashlib.sha256(b).hexdigest())"
# expect: 594542f909d8b3642ae4ed4c7d968112e8c12dfdf89bc2f96d95124df5abb431
Canonical record JSON
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