CRANE applies a Hidden Markov Model to correct errors in raw nanopore signals and reports consistent accuracy gains for downstream raw-signal analysis tools with low added compute cost.
Error rates for nanopore discrimination among cytosine, methyl- 8 cytosine, and hydroxymethylcytosine along individual DNA strands
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CRANE: Correcting Errors in Raw Nanopore Signals Using Hidden Markov Models
CRANE applies a Hidden Markov Model to correct errors in raw nanopore signals and reports consistent accuracy gains for downstream raw-signal analysis tools with low added compute cost.