A prompt-refined LLM workflow extracts TPD assay records with F1 scores above 0.93 from few expert examples, expanding molecular glue and PROTAC databases by 81% and 92% with over 82% expert-validated accuracy.
Pubchem 2025 update.Nucleic Acids Research, 53(D1):D1516– D1525
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Beyond Manual Curation: Augmenting Targeted Protein Degradation Databases via Agentic Literature Extraction Workflows
A prompt-refined LLM workflow extracts TPD assay records with F1 scores above 0.93 from few expert examples, expanding molecular glue and PROTAC databases by 81% and 92% with over 82% expert-validated accuracy.