Finite-horizon optimal e-value designs for adaptive single-arm binary trials are constructed via dynamic programming and shown to have competitive operating characteristics with automatic futility indication.
Christopher Jennison and Bruce W
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Adaptive clinical trials based on design-optimal e-values with automatic curtailment: An application to single-arm trials with binary data
Finite-horizon optimal e-value designs for adaptive single-arm binary trials are constructed via dynamic programming and shown to have competitive operating characteristics with automatic futility indication.