SpliceBind is a GNN framework for isoform-aware binding pocket druggability prediction that achieves AUROC 0.703 on 229 kinase pockets and identifies structural limits for certain resistance mechanisms.
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SpliceBind: Isoform-Aware Prediction of Binding Pocket Druggability
SpliceBind is a GNN framework for isoform-aware binding pocket druggability prediction that achieves AUROC 0.703 on 229 kinase pockets and identifies structural limits for certain resistance mechanisms.