HADACA3 benchmark shows DNAm alone yields highest median deconvolution performance across datasets; multi-omics integration improves peak performance in select cases but does not raise average performance.
Senescence-associated DNA methylation is stochastically acquired in subpopulations of mesenchymal stem cells
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On the Promises and Limits of Multi-omics Integration for Deconvolution: The HADACA3 Benchmark
HADACA3 benchmark shows DNAm alone yields highest median deconvolution performance across datasets; multi-omics integration improves peak performance in select cases but does not raise average performance.