15N enrichment raises alpha-induced DSB++ by 175% and carbon-induced by 53% in simulations, while 15N-glutamine treatment yields 15% more cell death after 2 Gy irradiation with no added cytotoxicity.
Relative biological effectiveness (RBE) values for proton beam therapy
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Simulation of complex DNA damage enhancement and biological effect validation for Proton-CAT
15N enrichment raises alpha-induced DSB++ by 175% and carbon-induced by 53% in simulations, while 15N-glutamine treatment yields 15% more cell death after 2 Gy irradiation with no added cytotoxicity.
- Combined photon-proton modeling of radiation-induced brain imaging changes supports variability in proton relative biological effectiveness and increased periventricular radiosensitivity