TR-CIE sampler improves DFM sampling quality under limited NFE via schedule-based time reparameterization and cumulative-intensity extrapolation without extra model calls.
Multi-objective-guided discrete flow matching for controllable biological sequence design
2 Pith papers cite this work. Polarity classification is still indexing.
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2026 2verdicts
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MP2D is a framework that guides discrete diffusion denoising with constrained MCTS and Pareto rewards to optimize protein sequences for four to five simultaneous objectives, outperforming baselines on antimicrobial peptide and binder design tasks.
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A Time-Reparameterized Cumulative Intensity Extrapolation Sampler for Discrete Flow Matching
TR-CIE sampler improves DFM sampling quality under limited NFE via schedule-based time reparameterization and cumulative-intensity extrapolation without extra model calls.
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MP2D: Constrained Monte Carlo Tree-Guided Diffusion for Multi-Objective Protein Sequence Design
MP2D is a framework that guides discrete diffusion denoising with constrained MCTS and Pareto rewards to optimize protein sequences for four to five simultaneous objectives, outperforming baselines on antimicrobial peptide and binder design tasks.