ORBIT uses an intervention-consistent self-supervised objective in a transformer to infer asymmetric gene program influences from observational scRNA-seq data, recovering Alzheimer's vulnerability patterns and achieving 0.984 macro F1 cell-type classification from 220 pathway scores.
Mootha, Sayan Mukherjee, Benjamin L
1 Pith paper cite this work. Polarity classification is still indexing.
1
Pith paper citing it
fields
q-bio.GN 1years
2026 1verdicts
UNVERDICTED 1representative citing papers
citing papers explorer
-
ORBIT: Learning Gene Program Co-Activation Structure for Cell-Type-Stratified Pathway Rewiring Analysis in Single-Cell Transcriptomics
ORBIT uses an intervention-consistent self-supervised objective in a transformer to infer asymmetric gene program influences from observational scRNA-seq data, recovering Alzheimer's vulnerability patterns and achieving 0.984 macro F1 cell-type classification from 220 pathway scores.