Shesha quantifies directional coherence of single-cell CRISPR responses, correlates strongly with effect magnitude, distinguishes pleiotropic from lineage-specific regulators, and predicts chaperone activation after magnitude correction.
Dy- namics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape
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Geometric coherence of single-cell CRISPR perturbations reveals regulatory architecture and predicts cellular stress
Shesha quantifies directional coherence of single-cell CRISPR responses, correlates strongly with effect magnitude, distinguishes pleiotropic from lineage-specific regulators, and predicts chaperone activation after magnitude correction.