AssayBench is a new gene-ranking benchmark for phenotypic CRISPR screens that shows zero-shot generalist LLMs outperform both biology-specific LLMs and trainable baselines on adjusted nDCG.
arXiv preprint arXiv:2502.21290 , year=
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AROMA combines text, graph topology, and protein sequences with augmented reasoning and two-stage optimization to deliver more accurate and interpretable predictions of genetic perturbation effects in virtual cells, outperforming baselines even in zero-shot and long-tail settings.
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AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents
AssayBench is a new gene-ranking benchmark for phenotypic CRISPR screens that shows zero-shot generalist LLMs outperform both biology-specific LLMs and trainable baselines on adjusted nDCG.
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AROMA: Augmented Reasoning Over a Multimodal Architecture for Virtual Cell Genetic Perturbation Modeling
AROMA combines text, graph topology, and protein sequences with augmented reasoning and two-stage optimization to deliver more accurate and interpretable predictions of genetic perturbation effects in virtual cells, outperforming baselines even in zero-shot and long-tail settings.