Topological Change in Mean Convex Mean Curvature Flow

Consider the mean curvature flow of an (n+1)-dimensional, compact, mean convex region in Euclidean space (or, if n<7, in a Riemannian manifold). We prove that elements of the m-th homotopy group of the complementary region can die only if there is a shrinking S^k x R^(n-k) singularity for some k less than or equal to m. We also prove that for each m from 1 to n, there is a nonempty open set of compact, mean convex regions K in R^(n+1) with smooth boundary for which the resulting mean curvature flow has a shrinking S^m x R^(n-m) singularity.