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arxiv: 1404.5103 · v1 · pith:SNQP3423 · submitted 2014-04-21 · q-bio.NC

Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics

Adam H Marblestone , Evan R Daugharthy , Reza Kalhor , Ian D Peikon , Justus M Kebschull , Seth L Shipman , Yuriy Mishchenko , Je Hyuk Lee
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Konrad P Kording Edward S Boyden Anthony M Zador George M Church
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classification q-bio.NC
keywords fisseq-boincsequencingacidconnectomicsfluorescentnucleicstrategyannotations
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We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ). FISSEQ-BOINC exhibits different properties from BOINC, which relies on bulk nucleic acid sequencing. FISSEQ-BOINC could become a scalable approach for mapping whole-mammalian-brain connectomes with rich molecular annotations.

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