Two types of pyramidal cells and their role in temporal processing

Recent work has provided new insights into the temporal specialization of Intratelencephalic (IT) and Pyramidal tract neurons (PT). However, functional and anatomical differences of IT and PT have not been connected yet. This perspective article contributes by highlighting empirical studies about the connectivity of IT and PT as well as their specialization in sensory and motor processing in diverse brain regions. We further review conceptual models that would align with the connectivity motif. We conclude that further research is needed to understand the role of the unidirectional connectivity from IT to PT in temporal processing and suggest concrete experiments.