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This study mainly explores the application of natural gesture recognition based on computer vision in human-computer interaction, aiming to improve the fluency and naturalness of human-computer interaction through gesture recognition technology. In the fields of virtual reality, augmented reality and smart home, traditional input methods have gradually failed to meet the needs of users for interactive experience. As an intuitive and convenient interaction method, gestures have received more and more attention. This paper proposes a gesture recognition method based on a three-dimensional hand skeleton model. By simulating the three-dimensional spatial distribution of hand joints, a simplified hand skeleton structure is constructed. By connecting the palm and each finger joint, a dynamic and static gesture model of the hand is formed, which further improves the accuracy and efficiency of gesture recognition. Experimental results show that this method can effectively recognize various gestures and maintain high recognition accuracy and real-time response capabilities in different environments. In addition, combined with multimodal technologies such as eye tracking, the intelligence level of the gesture recognition system can be further improved, bringing a richer and more intuitive user experience. In the future, with the continuous development of computer vision, deep learning and multimodal interaction technology, natural interaction based on gestures will play an important role in a wider range of application scenarios and promote revolutionary progress in human-computer interaction.