Identification of Genetic Factors Associated with Corpus Callosum Morphology: Conditional Strong Independence Screening for Non-Euclidean Responses

The corpus callosum, the largest white matter structure in the brain, plays a critical role in interhemispheric communication. Variations in its morphology are associated with various neurological and psychological conditions, making it a key focus in neurogenetics. Age is known to influence the structure and morphology of the corpus callosum significantly, complicating the identification of specific genetic factors that contribute to its shape and size. We propose a conditional strong independence screening method to address these challenges for ultrahigh-dimensional predictors and non-Euclidean responses. Our approach incorporates prior knowledge, such as age. It introduces a novel concept of conditional metric dependence, quantifying non-linear conditional dependencies among random objects in metric spaces without relying on predefined models. We apply this framework to identify genetic factors associated with the morphology of the corpus callosum. Simulation results demonstrate the efficacy of this method across various non-Euclidean data types, highlighting its potential to drive genetic discovery in neuroscience.