Not yet reviewed by Pith; the record is open.

Wave-particle duality is known to be equivalent to an entropic uncertainty relation based on the min- and max-entropies, which have a clear operational meaning in quantum cryptography. Here, we derive a connection between wave-particle relations and the semi-device-independent (SDI) security framework. In particular, we express an SDI witness entirely in terms of two complementary interferometric quantities: visibility and input distinguishability. Applying a symmetry condition to the interferometric quantities, we identify a scenario in which the classical bound is violated and the security condition is met in wave-particle experiments with a tunable beam splitter. This enables the certification of non-classicality and the positivity of the key rate directly from complementary interferometric quantities. Moreover, we perform a proof-of-principle experiment using orbital-angular-momentum encoded quantum states of light in a tunable interferometer, validating our theoretical predictions. Finally, we analyze an improved bound on the SDI security condition, effectively enlarging the parameter region where secure communication can be certified.