Missing and spurious interaction in additive, multiplicative and odds ratio models

(2) Center of Molecular Immunology; (3) Institute for Protein Research); Biotechnology; Jorge Fernandez-de-Cossio (1); Jorge Fernandez-de-Cossio-Diaz (2); Toshifumi Takao (3); Yasser Perera (1) ((1) Center for Genetic Engineering

arxiv: 1712.04412 · v1 · pith:EA5AHNSNnew · submitted 2017-12-12 · 🧬 q-bio.OT

Missing and spurious interaction in additive, multiplicative and odds ratio models

Jorge Fernandez-de-Cossio (1) , Jorge Fernandez-de-Cossio-Diaz (2) , Toshifumi Takao (3) , Yasser Perera (1) ((1) Center for Genetic Engineering , Biotechnology , (2) Center of Molecular Immunology , (3) Institute for Protein Research) This is my paper

classification 🧬 q-bio.OT

keywords interactionsmodelsadditiveadvocatedmissingmultiplicativeratiospurious

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Additive, multiplicative, and odd ratio neutral models for interactions are for long advocated and controversial in epidemiology. We show here that these commonly advocated models are biased, leading to spurious interactions, and missing true interactions.

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Missing and spurious interaction in additive, multiplicative and odds ratio models

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