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arxiv: 1608.06924 · v1 · pith:LPPRARUZnew · submitted 2016-08-15 · 🧬 q-bio.OT

Hypothesis: Homologous recombination depends on parallel search

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keywords homologousrecombinationsearchbreakbrokencellchromosomecorresponding
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It is not known how a cell manages to find a specific DNA sequence sufficiently fast to repair a broken chromosome through homologous recombination. I propose that the solution is based on a parallelized search implemented by freely diffusing molecules programmed with sequences corresponding to those flanking the break site.

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