PerturbedVAE disentangles perturbation-specific signals from invariant gene expression structure to recover causal representations and improve out-of-distribution prediction in single-cell perturbation modeling.
Nature methods , volume=
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AblateCell reproduces baselines in three single-cell perturbation repositories with 88.9% success and recovers ground-truth critical components with 93.3% accuracy via closed-loop ablation.