DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.
Score- based generative modeling through stochastic differential equations
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Drifting with Gaussian kernels exactly matches score-matching on smoothed distributions via Tweedie's formula, while Laplace kernels approximate this closely in high dimensions.
Aligning the DDIM forward diffusion process with flow-matching manifold evolution enables high-quality generation without time conditioning, and class-conditional synthesis is possible with an unconditional denoiser by using separate time spaces per class.
citing papers explorer
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Towards A Generative Protein Evolution Machine with DPLM-Evo
DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.
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A Unified View of Score-Based and Drifting Models
Drifting with Gaussian kernels exactly matches score-matching on smoothed distributions via Tweedie's formula, while Laplace kernels approximate this closely in high dimensions.
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Exploring Time Conditioning in Diffusion Generative Models from Disjoint Noisy Data Manifolds
Aligning the DDIM forward diffusion process with flow-matching manifold evolution enables high-quality generation without time conditioning, and class-conditional synthesis is possible with an unconditional denoiser by using separate time spaces per class.