Chem2Gen-Bench is a new benchmark and evaluation framework for measuring alignment between chemical and genetic perturbation responses in matched cell-target contexts using retrieval, similarity, and embedding comparisons.
URL https://www.biorxiv.org/content/early/2025/08/ 21/2025.08.18.670981
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Chem2Gen-Bench: Benchmarking Chemical-to-Genetic Translation in Perturbation Response Space
Chem2Gen-Bench is a new benchmark and evaluation framework for measuring alignment between chemical and genetic perturbation responses in matched cell-target contexts using retrieval, similarity, and embedding comparisons.
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Towards Autonomous Mechanistic Reasoning in Virtual Cells
VCR-Agent uses mechanistic action graphs and verifier filtering to autonomously produce validated biological explanations from the Tahoe-100M atlas, yielding the VC-TRACES dataset that improves factual precision and gene expression prediction when used for training.