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arxiv: 1112.2836 · v1 · pith:2GJ4OXTYnew · submitted 2011-12-13 · 🧮 math-ph · math.MP· math.PR· q-bio.PE

Mean field mutation dynamics and the continuous Luria-Delbr\"uck distribution

classification 🧮 math-ph math.MPmath.PRq-bio.PE
keywords distributionluria-delbrcontinuouscorrespondingfieldmeanmutationanalysis
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The Luria-Delbr\"uck mutation model has a long history and has been mathematically formulated in several different ways. Here we tackle the problem in the case of a continuous distribution using some mathematical tools from nonlinear statistical physics. Starting from the classical formulations we derive the corresponding differential models and show that under a suitable mean field scaling they correspond to generalized Fokker-Planck equations for the mutants distribution whose solutions are given by the corresponding Luria-Delbr\"uck distribution. Numerical results confirming the theoretical analysis are also presented.

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