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A Survey of LLM-based Agents in Medicine: How far are we from Baymax?

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arxiv 2502.11211 v2 pith:IO6KIMIC submitted 2025-02-16 cs.CL cs.AIcs.CV

classification cs.CLcs.AIcs.CV
keywords agentsllm-basedmedicalhealthcaresurveyincludingmedicinearchitectures
verification ladder T0 review T1 audit T2 compute T3 formal
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Large Language Models (LLMs) are transforming healthcare through the development of LLM-based agents that can understand, reason about, and assist with medical tasks. This survey provides a comprehensive review of LLM-based agents in medicine, examining their architectures, applications, and challenges. We analyze the key components of medical agent systems, including system profiles, clinical planning mechanisms, medical reasoning frameworks, and external capacity enhancement. The survey covers major application scenarios such as clinical decision support, medical documentation, training simulations, and healthcare service optimization. We discuss evaluation frameworks and metrics used to assess these agents' performance in healthcare settings. While LLM-based agents show promise in enhancing healthcare delivery, several challenges remain, including hallucination management, multimodal integration, implementation barriers, and ethical considerations. The survey concludes by highlighting future research directions, including advances in medical reasoning inspired by recent developments in LLM architectures, integration with physical systems, and improvements in training simulations. This work provides researchers and practitioners with a structured overview of the current state and future prospects of LLM-based agents in medicine.

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Forward citations

Cited by 7 Pith papers

Reviewed papers in the Pith corpus that reference this work. Sorted by Pith novelty score. OpenAlex reports about 11 citations worldwide. Full citation record

  1. AUTOCT: Automating Interpretable Clinical Trial Prediction with LLM Agents

    cs.LG 2025-06 reject novelty 6.0 of 10

    AutoCT achieves test ROC-AUC 0.753, 0.639, and 0.702 on Phase I/II/III trial approval prediction using 100-sample subsets and LLM-generated features.

  2. MedSentry: Understanding and Mitigating Safety Risks in Medical LLM Multi-Agent Systems

    cs.MA 2025-05 conditional novelty 6.0 of 10

    A 5,000-prompt medical safety benchmark reveals that decentralized LLM multi-agent teams resist a malicious insider agent better than shared-pool teams, and a personality-screening defense partially restores safety.

  3. Scaling LLM-Driven Multi-Agent Systems: Design Principles and Architectural Scalability Analysis

    cs.MA 2026-07 conditional novelty 5.0 of 10

    Architecturally scaling LLM multi-agent systems raises accuracy at near-linear cost only above a model-capability threshold, peaks at intermediate complexity, and never fixes poor run-to-run consistency.

  4. Can Agents Distinguish Visually Hard-to-Separate Diseases in a Zero-Shot Setting? A Pilot Study

    cs.CV 2026-02 conditional novelty 5.0 of 10

    A prompt-only multi-agent system improves zero-shot accuracy on visually confounded medical image pairs (melanoma vs atypical nevus: 66.5% to 77.6%) but remains below clinical threshold.

  5. CT-Agent: A Multimodal-LLM Agent for 3D CT Radiology Question Answering

    cs.CV 2025-05 conditional novelty 5.0 of 10

    CT-Agent combines an LLM planner, region-specific LoRA adapters, and global/local token compression to improve 3D chest CT report generation and question answering on CT-RATE and RadGenome-ChestCT.

  6. A Comprehensive Survey of Electronic Health Record Modeling: From Deep Learning Approaches to Large Language Models

    cs.LG 2025-07 reject novelty 4.0 of 10

    A survey that taxonomizes EHR modeling research into data-centric, architectural, learning-focused, multimodal, and LLM-based categories, with datasets and metrics.

  7. A Call for Collaborative Intelligence: Why Human-Agent Systems Should Precede AI Autonomy

    cs.AI 2025-06 conditional novelty 4.0 of 10

    A position paper arguing that LLM-based human-agent systems, not fully autonomous agents, should be the immediate goal for AI development.

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