VibeProteinBench is a new benchmark evaluating LLMs on open-ended language-interfaced protein design across recognition, engineering, and generation, with no model showing strong performance in all areas.
Progen2: exploring the boundaries of protein language models.Cell systems, 14(11):968–978
3 Pith papers cite this work. Polarity classification is still indexing.
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2026 3verdicts
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ProteinOPD uses token-level on-policy distillation from multiple preference-specific teacher models into a shared student to balance competing objectives in protein design, delivering gains on targets without losing designability and an 8x speedup over RL baselines.
SGRPO expands the utility-diversity Pareto frontier in biomolecular design by using supergroup sampling and leave-one-out diversity rewards combined with utility signals.
citing papers explorer
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ProteinOPD: Towards Effective and Efficient Preference Alignment for Protein Design
ProteinOPD uses token-level on-policy distillation from multiple preference-specific teacher models into a shared student to balance competing objectives in protein design, delivering gains on targets without losing designability and an 8x speedup over RL baselines.