A-CODE presents a fully atomic one-stage multimodal diffusion model for protein co-design that claims superior unconditional generation performance over prior one- and two-stage models plus a tenfold success-rate gain on hard binder-design tasks.
Dplm-2: A multimodal diffusion protein language model
7 Pith papers cite this work. Polarity classification is still indexing.
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LLaDA is a scalable diffusion-based language model that matches autoregressive LLMs like LLaMA3 8B on tasks and surpasses GPT-4o on reversal poem completion.
ΔLPS is a gradient-guided discrete posterior sampler for inverse problems that works with masked or uniform discrete diffusion priors and outperforms prior discrete methods on image restoration tasks.
Yeti is a compact tokenizer for protein structures that delivers strong codebook use, token diversity, and reconstruction while enabling from-scratch multimodal generation of plausible sequences and structures with 10x fewer parameters than ESM3.
Coupling Models enable single-step discrete sequence generation via learned couplings to Gaussian latents and outperform prior one-step baselines on text perplexity, biological FBD, and image FID metrics.
DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.
CodeFP jointly generates protein sequences and structures using functional local structures and auxiliary supervision, yielding 6.1% better functional consistency and 3.2% better foldability than prior baselines.
citing papers explorer
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A-CODE: Fully Atomic Protein Co-Design with Unified Multimodal Diffusion
A-CODE presents a fully atomic one-stage multimodal diffusion model for protein co-design that claims superior unconditional generation performance over prior one- and two-stage models plus a tenfold success-rate gain on hard binder-design tasks.
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Large Language Diffusion Models
LLaDA is a scalable diffusion-based language model that matches autoregressive LLMs like LLaMA3 8B on tasks and surpasses GPT-4o on reversal poem completion.
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Discrete Langevin-Inspired Posterior Sampling
ΔLPS is a gradient-guided discrete posterior sampler for inverse problems that works with masked or uniform discrete diffusion priors and outperforms prior discrete methods on image restoration tasks.
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Yeti: A compact protein structure tokenizer for reconstruction and multi-modal generation
Yeti is a compact tokenizer for protein structures that delivers strong codebook use, token diversity, and reconstruction while enabling from-scratch multimodal generation of plausible sequences and structures with 10x fewer parameters than ESM3.
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Coupling Models for One-Step Discrete Generation
Coupling Models enable single-step discrete sequence generation via learned couplings to Gaussian latents and outperform prior one-step baselines on text perplexity, biological FBD, and image FID metrics.
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Towards A Generative Protein Evolution Machine with DPLM-Evo
DPLM-Evo adds explicit edit operations and a latent alignment space to discrete diffusion protein models, achieving SOTA single-sequence mutation effect prediction on ProteinGym while supporting variable-length generation.
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Co-Generative De Novo Functional Protein Design
CodeFP jointly generates protein sequences and structures using functional local structures and auxiliary supervision, yielding 6.1% better functional consistency and 3.2% better foldability than prior baselines.