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TauPETGen: Text-Conditional Tau PET Image Synthesis Based on Latent Diffusion Models
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In this work, we developed a novel text-guided image synthesis technique which could generate realistic tau PET images from textual descriptions and the subject's MR image. The generated tau PET images have the potential to be used in examining relations between different measures and also increasing the public availability of tau PET datasets. The method was based on latent diffusion models. Both textual descriptions and the subject's MR prior image were utilized as conditions during image generation. The subject's MR image can provide anatomical details, while the text descriptions, such as gender, scan time, cognitive test scores, and amyloid status, can provide further guidance regarding where the tau neurofibrillary tangles might be deposited. Preliminary experimental results based on clinical [18F]MK-6240 datasets demonstrate the feasibility of the proposed method in generating realistic tau PET images at different clinical stages.
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Cited by 1 Pith paper
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Cyclic 2.5D Perceptual Loss for Cross-Modal 3D Medical Image Synthesis: T1w MRI to Tau PET
Proposes a cyclic 2.5D perceptual loss with manufacturer SUVR standardization for T1w MRI to tau PET synthesis, reporting improved regional agreement on ADNI and SCAN cohorts across U-Net, UNETR, SwinUNETR, CycleGAN, ...
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