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U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation

38 Pith papers cite this work. Polarity classification is still indexing.

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abstract

Convolutional Neural Networks (CNNs) and Transformers have been the most popular architectures for biomedical image segmentation, but both of them have limited ability to handle long-range dependencies because of inherent locality or computational complexity. To address this challenge, we introduce U-Mamba, a general-purpose network for biomedical image segmentation. Inspired by the State Space Sequence Models (SSMs), a new family of deep sequence models known for their strong capability in handling long sequences, we design a hybrid CNN-SSM block that integrates the local feature extraction power of convolutional layers with the abilities of SSMs for capturing the long-range dependency. Moreover, U-Mamba enjoys a self-configuring mechanism, allowing it to automatically adapt to various datasets without manual intervention. We conduct extensive experiments on four diverse tasks, including the 3D abdominal organ segmentation in CT and MR images, instrument segmentation in endoscopy images, and cell segmentation in microscopy images. The results reveal that U-Mamba outperforms state-of-the-art CNN-based and Transformer-based segmentation networks across all tasks. This opens new avenues for efficient long-range dependency modeling in biomedical image analysis. The code, models, and data are publicly available at https://wanglab.ai/u-mamba.html.

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representative citing papers

DyABD: The Abdominal Muscle Segmentation in Dynamic MRI Benchmark

cs.CV · 2026-04-25 · conditional · novelty 9.0

DyABD is the first benchmark dataset for abdominal muscle segmentation in dynamic MRIs featuring exercise-induced anatomical changes and pre/post-surgery scans, where existing models achieve an average Dice score of 0.82.

MHMamba: Multi-Head Mamba for 3D Brain Tumor Segmentation

cs.CV · 2026-05-15 · unverdicted · novelty 5.0

MHMamba combines a U-Net with multi-head Mamba, channel calibration, and adaptive skip fusion to improve 3D brain tumor segmentation accuracy and small-lesion sensitivity on BraTS datasets while retaining linear complexity.

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